Estrogen Receptor Beta-Mediated Proliferative Inhibition and Apoptosis in Human Breast Cancer by Calycosin and Formononetin | Zendy

Jian Chen | Zendy; Xinge Zhao | Zendy; Yu Ye | Zendy; Y. Wang | Zendy; Jing Tian | Zendy

Open Access

Estrogen Receptor Beta-Mediated Proliferative Inhibition and Apoptosis in Human Breast Cancer by Calycosin and Formononetin

Author(s) -

Jian Chen,

Xinge Zhao,

Yu Ye,

Y. Wang,

Jing Tian

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356612

Subject(s) - calycosin , formononetin , estrogen receptor , apoptosis , mcf 7 , cell growth , cancer research , breast cancer , flow cytometry , isoflavones , chemistry , cancer cell , cancer , medicine , biology , microbiology and biotechnology , biochemistry , genistein , human breast , daidzein

Calycosin and formononetin are two main components of isoflavones. In our previous studies, we have respectively reported their antitumor activities on breast cancer cell MCF-7. To further investigate the feasibility of isoflavones in clinically treating breast carcinoma, here we specifically focused on the comparison between calycosin and formononetin, along with the relevant mechanism.

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