Alteration of Mevalonate Pathway Related Enzyme Expressions in Pressure Overload-Induced Cardiac Hypertrophy and Associated Heart Failure with Preserved Ejection Fraction | Zendy

Bin Chen | Zendy; Liyun Zhong | Zendy; Jinxiu Yang | Zendy; Yanyun Pan | Zendy; Fei Chen | Zendy; Jian Yang | Zendy; Tao Wu | Zendy; ShenJiang Hu | Zendy

Open Access

Alteration of Mevalonate Pathway Related Enzyme Expressions in Pressure Overload-Induced Cardiac Hypertrophy and Associated Heart Failure with Preserved Ejection Fraction

Author(s) -

Bin Chen,

Liyun Zhong,

Jinxiu Yang,

Yanyun Pan,

Fei Chen,

Jian Yang,

Tao Wu,

ShenJiang Hu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356610

Subject(s) - pressure overload , farnesyltransferase , heart failure , medicine , endocrinology , muscle hypertrophy , mevalonate pathway , ejection fraction , blood pressure , diastole , cardiology , biology , reductase , enzyme , biochemistry , cardiac hypertrophy , prenylation

Abnormalities of the mevalonate pathway, an important cellular metabolic pathway, are common in many diseases including cardiovascular disease. The mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated diastolic dysfunction remains largely unknown. This study aims to investigate whether the expression of mevalonate pathway related enzyme is altered during the progression of cardiac hypertrophy and associated diastolic dysfunction induced by pressure overload.

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