Up-Regulated Expression of miR-23a/b Targeted the Pro-Apoptotic Fas in Radiation-Induced thymic Lymphoma
Author(s) -
Bailong Li,
Mingjuan Sun,
Fu Gao,
Wen Liu,
Yanyong Yang,
Hu Liu,
Ying Cheng,
Cong Liu,
Jianming Cai
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000356607
Subject(s) - microrna , apoptosis , transfection , cancer research , microbiology and biotechnology , biology , carcinogenesis , lymphoma , messenger rna , untranslated region , three prime untranslated region , luciferase , reporter gene , gene expression , cell culture , gene , immunology , genetics
MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs, which usually bind to the 3'-untranslated region of target mRNAs and are capable of inducing posttranscriptional gene regulation by blocking translation or by degrading the target mRNA. However, the expression level of miR-23 in radiation induced carcinogenesis is largely unknown.
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