Demethylation of miR-9-3 and miR-193a Genes Suppresses Proliferation and Promotes Apoptosis in Non-Small Cell Lung Cancer Cell Lines | Zendy

Jinliang Wang | Zendy; Bo Yang | Zendy; Lu Han | Zendy; Xiaoyan Li | Zendy; Haitao Tao | Zendy; Sujie Zhang | Zendy; Yi Hu | Zendy

Open Access

Demethylation of miR-9-3 and miR-193a Genes Suppresses Proliferation and Promotes Apoptosis in Non-Small Cell Lung Cancer Cell Lines

Author(s) -

Jinliang Wang,

Bo Yang,

Lu Han,

Xiaoyan Li,

Haitao Tao,

Sujie Zhang,

Yi Hu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356605

Subject(s) - cell growth , cancer research , microrna , biology , apoptosis , methylation , dna methylation , gene knockdown , population , microbiology and biotechnology , flow cytometry , downregulation and upregulation , gene expression , medicine , gene , genetics , environmental health

MicroRNAs miR-9-3 and miR-193a have recently been found to be hypermethylated in a variety of non-small cell lung cancer (NSCLC) cells and primary human tumors. The objectives of this study were to investigate the role of demethylation of miR-9-3 and miR-193a genes in regulating proliferation and apoptosis in NSCLCs, and to decipher the potential mechanisms underlying the properties.

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