Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting p38MAPK/NF&#954;B Pathway in H9c2 Cardiac Cells | Zendy

Runmin Guo | Zendy; Keng Wu | Zendy; Jingfu Chen | Zendy; Liqiu Mo | Zendy; Xiaoxiao Hua | Zendy; Dongdan Zheng | Zendy; Peixi Chen | Zendy; Gang Chen | Zendy; Wenming Xu | Zendy; Jianqiang Feng | Zendy

Open Access

Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting p38MAPK/NFκB Pathway in H9c2 Cardiac Cells

Author(s) -

Runmin Guo,

Keng Wu,

Jingfu Chen,

Liqiu Mo,

Xiaoxiao Hua,

Dongdan Zheng,

Peixi Chen,

Gang Chen,

Wenming Xu,

Jianqiang Feng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356602

Subject(s) - cytotoxicity , p38 mitogen activated protein kinases , tumor necrosis factor alpha , mapk/erk pathway , chemistry , nitric oxide synthase , pharmacology , viability assay , nf κb , doxorubicin , inflammation , protein kinase a , nitric oxide , signal transduction , kinase , biology , medicine , cell , biochemistry , endocrinology , immunology , in vitro , chemotherapy , organic chemistry

We have demonstrated that exogenous hydrogen sulfide (H2S) protects H9c2 cardiac cells against the doxorubicin (DOX)-induced injuries by inhibiting p38 mitogen-activated protein kinase (MAPK) pathway and that the p38 MAPK/nuclear factor-κB (NF-κB) pathway is involved in the DOX-induced inflammatory response and cytotoxicity. The present study attempts to test the hypothesis that exogenous H2S might protect cardiomyocytes against the DOX-induced inflammation and cytotoxicity through inhibiting p38 MAPK/NF-κB pathway.

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