Stearic Acid Serves as a Potent Inhibitor of Protein Tyrosine Phosphatase 1B | Zendy

Ayako Tsuchiya | Zendy; Takeshi Kanno | Zendy; Tomoyuki Nishizaki | Zendy

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Stearic Acid Serves as a Potent Inhibitor of Protein Tyrosine Phosphatase 1B

Author(s) -

Ayako Tsuchiya,

Takeshi Kanno,

Tomoyuki Nishizaki

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356582

Subject(s) - protein kinase b , insulin , stearic acid , insulin receptor , phosphorylation , glucose uptake , tyrosine phosphorylation , medicine , endocrinology , chemistry , signal transduction , insulin receptor substrate , protein tyrosine phosphatase , biochemistry , phosphatase , biology , insulin resistance , organic chemistry

Free fatty acids (FFAs) are implicated in diverse signal transduction pathways. The present study investigated the effects of the saturated FFA stearic acid on protein tyrosine phosphatase 1B (PTP1B) activity, Akt activity, and glucose uptake into cells relevant to insulin signal.

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