Estramustine-Induced Suicidal Erythrocyte Death | Zendy

Rosi Bissinger | Zendy; Paola Modicano | Zendy; Leonie Frauenfeld | Zendy; Elisabeth Lang | Zendy; Janin Jacobi | Zendy; Caterina Faggio | Zendy; Florian Läng | Zendy

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Estramustine-Induced Suicidal Erythrocyte Death

Author(s) -

Rosi Bissinger,

Paola Modicano,

Leonie Frauenfeld,

Elisabeth Lang,

Janin Jacobi,

Caterina Faggio,

Florian Läng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356580

Subject(s) - estramustine , phosphatidylserine , apoptosis , programmed cell death , cytosol , annexin , chemistry , medicine , extracellular , endocrinology , microbiology and biotechnology , biology , biochemistry , prostate cancer , phospholipid , cancer , membrane , prostate disease , enzyme

The nitrogen mustard derivative of estradiol-17β-phosphate estramustine is used for the treatment of prostate cancer. Estramustine may trigger suicidal death of cancer cells. Side effects of estramustine include anemia. At least in theory, estramustine could cause anemia by stimulation of eryptosis, the suicidal death of erythrocytes. Hallmarks of eryptosis include cell shrinkage, increased cytosolic Ca2+ activity ([Ca2+]), ceramide formation and phosphatidylserine translocation to the outer leaflet of the cell membrane with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is stimulated by increase of cytosolic Ca2+ activity ([Ca2+]i). The present study explored whether estramustine triggers eryptosis.

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