The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity | Zendy

Luca Giudici | Zendy; Ana Velić | Zendy; Arezoo Daryadel | Zendy; Carla Bettoni | Zendy; Nilufar Mohebbi | Zendy; Thomas Suply | Zendy; Klaus Seuwen | Zendy; MarieGabrielle Ludwig | Zendy; Carsten A. Wagner | Zendy

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The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity

Author(s) -

Luca Giudici,

Ana Velić,

Arezoo Daryadel,

Carla Bettoni,

Nilufar Mohebbi,

Thomas Suply,

Klaus Seuwen,

MarieGabrielle Ludwig,

Carsten A. Wagner

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356578

Subject(s) - endocrinology , medicine , adipose tissue , white adipose tissue , glucose homeostasis , insulin , receptor , leptin , insulin receptor , skeletal muscle , homeostasis , insulin resistance , biology , obesity

The proton-activated G protein-coupled receptor GPR4 is expressed in many tissues including white adipose tissue. GPR4 is activated by extracellular protons in the physiological pH range (i.e. pH 7.7 - 6.8) and is coupled to the production of cAMP.

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