Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays | Zendy

Julia M. Mehnert | Zendy; Matthias Brandenburger | Zendy; Bianka Grunow | Zendy

Open Access

Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays

Author(s) -

Julia M. Mehnert,

Matthias Brandenburger,

Bianka Grunow

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000356576

Subject(s) - herg , dofetilide , electrophysiology , pharmacology , cardiac electrophysiology , rainbow trout , potassium channel , contraction (grammar) , medicine , neuroscience , biology , qt interval , fishery , fish <actinopterygii>

Safety pharmacology requires novel model systems for the detection of cardiac side effects. Ranging from cell-based systems to model organisms, no model available to date reflects the complexity of the human heart and evokes the great need for improved and more affordable systems. Many drugs interact with hERG potassium channels and consequently cause life threatening ventricular arrhythmias, further highlighting the importance of suitable model systems.

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