Open AccessNovel Use of Rituximab for Steroid-Dependent Nephrotic Syndrome in Children
Author(s) -
Takahisa Kimata,
Masafumi Hasui,
Jiro Kino,
Tetsuya Kitao,
Sohsaku Yamanouchi,
Shoji Tsuji,
Kazunari Kaneko
Publication year - 2013
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000356439
Subject(s) - medicine , nephrotic syndrome , rituximab , gastroenterology , regimen , lymphoma
Though rituximab (RTX) is effective for childhood steroid-dependent nephrotic syndrome (SDNS), an established regimen does not exist. The relapses tend to occur when the peripheral blood B-cell count re-arises at 3 months upon single RTX infusion. This study was conducted to clarify whether the long-term remission of SDNS can be obtained by repeated RTX administrations.
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