Cytotoxic Effects of p-Cresol in Renal Epithelial Tubular Cells | Zendy

Alessandra Brocca | Zendy; Grazia Maria Virzì | Zendy; Massimo de Cal | Zendy; Vincenzo Cantaluppi | Zendy; Claudio Ronco | Zendy

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Cytotoxic Effects of <b><i>p</i></b>-Cresol in Renal Epithelial Tubular Cells

Author(s) -

Alessandra Brocca,

Grazia Maria Virzì,

Massimo de Cal,

Vincenzo Cantaluppi,

Claudio Ronco

Publication year - 2013

Publication title -

blood purification

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.686

H-Index - 57

eISSN - 1421-9735

pISSN - 0253-5068

DOI - 10.1159/000356370

Subject(s) - apoptosis , necrosis , kidney , toxin , programmed cell death , annexin , viability assay , incubation , dialysis , andrology , microbiology and biotechnology , endocrinology , medicine , chemistry , biology , biochemistry

The uremic syndrome is characterized by a deterioration of kidney function due to the accumulation of uremic toxins. Currently, 100 different uremic toxins have been identified. Uremic toxins are particularly difficult to remove by conventional dialysis treatments and are the major causes of mortality in patients with chronic kidney disease (CKD). p-Cresol is a well-known uremic toxin which accumulates in uremic serum. Our aim was to evaluate the in vitro effect of p-cresol on apoptosis and necrosis in renal tubular cells (RTCs) to better understand the pathophysiological effect of this toxin on the kidney.

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