The Role of Gastroesophageal Reflux in Relation to Symptom Onset in Patients with Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease Accompanied by an Underlying Esophageal Motor Disorder | Zendy

Shinya Izawa | Zendy; Yasushi Funaki | Zendy; Akihito Iida | Zendy; Kentaro Tokudome | Zendy; Yasuhiro Tamura | Zendy; Naotaka Ogasawara | Zendy; Makoto Sasaki | Zendy; Kunio Kasugai | Zendy

Open Access

The Role of Gastroesophageal Reflux in Relation to Symptom Onset in Patients with Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease Accompanied by an Underlying Esophageal Motor Disorder

Author(s) -

Shinya Izawa,

Yasushi Funaki,

Akihito Iida,

Kentaro Tokudome,

Yasuhiro Tamura,

Naotaka Ogasawara,

Makoto Sasaki,

Kunio Kasugai

Publication year - 2014

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000356222

Subject(s) - nerd , reflux , gastroenterology , medicine , proton pump inhibitor , gerd , refractory (planetary science) , achalasia , esophageal ph monitoring , esophageal motility disorder , high resolution manometry , disease , esophagus , physics , astrobiology

The symptom improvement rate is low with proton pump inhibitors (PPIs) in nonerosive reflux disease (NERD). The underlying pathogenic mechanism is complex. Esophageal motility disorders (EMDs) are thought to be a factor, but their prevalence, type, symptoms and the role played by gastroesophageal reflux (GER) in symptom onset have not been fully investigated.

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