Voluntary Wheel Running Does Not Affect Lipopolysaccharide-Induced Depressive-Like Behavior in Young Adult and Aged Mice | Zendy

Stephen A. Martin | Zendy; Robert Dantzer | Zendy; Keith W. Kelley | Zendy; Jeffrey A. Woods | Zendy

Open Access

Voluntary Wheel Running Does Not Affect Lipopolysaccharide-Induced Depressive-Like Behavior in Young Adult and Aged Mice

Author(s) -

Stephen A. Martin,

Robert Dantzer,

Keith W. Kelley,

Jeffrey A. Woods

Publication year - 2013

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000356144

Subject(s) - sickness behavior , behavioural despair test , endocrinology , medicine , lipopolysaccharide , tail suspension test , environmental enrichment , young adult , psychology , hippocampus , antidepressant

Peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes prolonged depressive-like behavior in aged mice that is dependent on indoleamine 2,3 dioxygenase (IDO) activation. Regular moderate-intensity exercise training has been shown to exert neuroprotective effects that might reduce depressive-like behavior in aged mice. The purpose of this study was to test the hypothesis that voluntary wheel running (VWR) would attenuate LPS-induced depressive-like behavior and brain IDO gene expression in 4- and 22-month-old C57BL/6J mice.

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