Vascular Endothelial Growth Factor in Acute Lung Injury and Acute Respiratory Distress Syndrome | Zendy

Shaney Barratt | Zendy; Andrew R L Medford | Zendy; Ann Millar | Zendy

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Vascular Endothelial Growth Factor in Acute Lung Injury and Acute Respiratory Distress Syndrome

Author(s) -

Shaney Barratt,

Andrew R L Medford,

Ann Millar

Publication year - 2013

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000356034

Subject(s) - ards , medicine , vascular endothelial growth factor , vascular permeability , lung , diffuse alveolar damage , acute respiratory distress , pathogenesis , respiratory distress , respiratory disease , pathology , anesthesia , vegf receptors

Acute respiratory distress syndrome (ARDS) is the most severe form of lung injury, characterised by alveolar oedema and vascular permeability, in part due to disruption of the alveolar capillary membrane integrity. Vascular endothelial growth factor (VEGF) was originally identified as a vascular permeability factor and has been implicated in the pathogenesis of acute lung injury/ARDS. This review describes our current knowledge of VEGF biology and summarises the literature investigating the potential role VEGF may play in normal lung maintenance and in the development of lung injury.

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