Prediction of Response to Pegylated Interferon/Ribavirin Combination Therapy for Chronic Hepatitis C Genotypes 2a and 2b and High Viral Load | Zendy

Soo Ryang Kim | Zendy; Ahmed ElShamy | Zendy; Susumu Imoto | Zendy; Ke Ih Kim | Zendy; Kayo Sugimoto | Zendy; Soo Ki Kim | Zendy; Yasuhito Tanaka | Zendy; Takashi Hatae | Zendy; Yutaka Hasegawa | Zendy; Aya Fujinami | Zendy; Mitsuhiro Ohta | Zendy; Hak Hotta | Zendy; Masatoshi Kudo | Zendy

Open Access

Prediction of Response to Pegylated Interferon/Ribavirin Combination Therapy for Chronic Hepatitis C Genotypes 2a and 2b and High Viral Load

Author(s) -

Soo Ryang Kim,

Ahmed ElShamy,

Susumu Imoto,

Ke Ih Kim,

Kayo Sugimoto,

Soo Ki Kim,

Yasuhito Tanaka,

Takashi Hatae,

Yutaka Hasegawa,

Aya Fujinami,

Mitsuhiro Ohta,

Hak Hotta,

Masatoshi Kudo

Publication year - 2013

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000355381

Subject(s) - ribavirin , pegylated interferon , medicine , genotype , snp , ns5a , single nucleotide polymorphism , hepatitis c virus , virology , viral load , interleukin 28b , gastroenterology , hepacivirus , virus , gene , biology , genetics

We investigated the impact of host genetics represented by the single nucleotide polymorphism (SNP) of the IL28B gene and viral genetic variations within the nonstructural protein 5A (NS5A) [including the interferon (IFN)/ribavirin (RBV) resistance-determining region (IRRDR) and the IFN sensitivity-determining region (ISDR)] on the outcome of pegylated IFN and RBV (PEG-IFN/RBV) treatment.

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