Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels | Zendy

Xavier F. Figueroa | Zendy; Daniel R. González | Zendy; Mariela Puebla | Zendy; Juan Pablo Acevedo | Zendy; Daniel RojasLíbano | Zendy; Walter N. Durán | Zendy; Mauricio P. Borić | Zendy

Open Access

Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels

Author(s) -

Xavier F. Figueroa,

Daniel R. González,

Mariela Puebla,

Juan Pablo Acevedo,

Daniel RojasLíbano,

Walter N. Durán,

Mauricio P. Borić

Publication year - 2013

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000355301

Subject(s) - enos , nitric oxide , nitric oxide synthase , phosphorylation , nitric oxide synthase type iii , wortmannin , medicine , chemistry , extracellular , cytosol , endocrinology , biology , protein kinase b , biochemistry , enzyme

Endothelial nitric oxide synthase (eNOS) is associated with caveolin-1 (Cav-1) in plasma membrane. We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-bound enzyme to Golgi and cytosol.

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