Hypothermia Protects against Fulminant Hepatitis in Mice by Reducing Reactive Oxygen Species Production | Zendy

Toshiharu Sakurai | Zendy; Masatoshi Kudo | Zendy; Tomohiro Watanabe | Zendy; Katsuhiko Itoh | Zendy; Hiroaki Higashitsuji | Zendy; Tadaaki Arizumi | Zendy; Tatsuo Inoue | Zendy; Satoru Hagiwara | Zendy; Kazuomi Ueshima | Zendy; Naoshi Nishida | Zendy; Manabu Fukumoto | Zendy; Jun Fujita | Zendy

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Hypothermia Protects against Fulminant Hepatitis in Mice by Reducing Reactive Oxygen Species Production

Author(s) -

Toshiharu Sakurai,

Masatoshi Kudo,

Tomohiro Watanabe,

Katsuhiko Itoh,

Hiroaki Higashitsuji,

Tadaaki Arizumi,

Tatsuo Inoue,

Satoru Hagiwara,

Kazuomi Ueshima,

Naoshi Nishida,

Manabu Fukumoto,

Jun Fujita

Publication year - 2013

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000355242

Subject(s) - hypothermia , medicine , galactosamine , fulminant hepatitis , concanavalin a , reactive oxygen species , protein kinase b , pharmacology , lipopolysaccharide , apoptosis , endocrinology , immunology , hepatitis , biochemistry , chemistry , in vitro , glucosamine

Mild hypothermia (32-33°C) shows protective effects in patients with brain damage and cardiac arrest. Although cold-inducible RNA-binding protein (CIRP) contributes to the protective effects of hypothermia through extracellular signal-regulated kinase activation in fibroblasts, the effects of hypothermia in the liver remain unclear.

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