Factors of Response to Pegylated Interferon/Ribavirin Combination Therapy and Mechanism of Viral Clearance | Zendy

Kumiko Sugimoto | Zendy; Soo Ryang Kim | Zendy; Ahmed El-Shamy | Zendy; Susumu Imoto | Zendy; Kenji Ando | Zendy; Ke Ih Kim | Zendy; Yasuhito Tanaka | Zendy; Yoshihiko Yano | Zendy; Soo Ki Kim | Zendy; Yutaka Hasegawa | Zendy; Aya Fujinami | Zendy; Mitsuhiro Ohta | Zendy; Takashi Hatori | Zendy; Hak Hotta | Zendy; Yoshitake Hayashi | Zendy; Masatoshi Kudo | Zendy

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Factors of Response to Pegylated Interferon/Ribavirin Combination Therapy and Mechanism of Viral Clearance

Author(s) -

Kumiko Sugimoto,

Soo Ryang Kim,

Ahmed El-Shamy,

Susumu Imoto,

Kenji Ando,

Ke Ih Kim,

Yasuhito Tanaka,

Yoshihiko Yano,

Soo Ki Kim,

Yutaka Hasegawa,

Aya Fujinami,

Mitsuhiro Ohta,

Takashi Hatori,

Hak Hotta,

Yoshitake Hayashi,

Masatoshi Kudo

Publication year - 2013

Publication title -

digestive diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.879

H-Index - 66

eISSN - 1421-9875

pISSN - 0257-2753

DOI - 10.1159/000355239

Subject(s) - ribavirin , medicine , pegylated interferon , combination therapy , gastroenterology , viral load , interferon , univariate analysis , immunology , multivariate analysis , virus , hepatitis c virus

This study explores viral factors of the interferon (IFN) and ribavirin (RBV) resistance-determining region (IRRDR), the IFN sensitivity-determining region (ISDR) and the core protein, and host factor interleukin 28B associated with response to pegylated IFN (PEG-IFN) and RBV combination therapy, and the correlation of viral and host factors with IFN-λ1.

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