Mast Cell-Deficient KitW-sh Mice Develop House Dust Mite-Induced Lung Inflammation despite Impaired Eosinophil Recruitment | Zendy

J. Daan de Boer | Zendy; Jack Yang | Zendy; Florry E. van den Boogaard | Zendy; Arie J. Hoogendijk | Zendy; Regina de Beer | Zendy; Jaring S. van der Zee | Zendy; Joris J. T. H. Roelofs | Zendy; Cornelis van ‘t Veer | Zendy; Alex F. de Vos | Zendy; Tom van der Poll | Zendy

Open Access

Mast Cell-Deficient KitW-sh Mice Develop House Dust Mite-Induced Lung Inflammation despite Impaired Eosinophil Recruitment

Author(s) -

J. Daan de Boer,

Jack Yang,

Florry E. van den Boogaard,

Arie J. Hoogendijk,

Regina de Beer,

Jaring S. van der Zee,

Joris J. T. H. Roelofs,

Cornelis van ‘t Veer,

Alex F. de Vos,

Tom van der Poll

Publication year - 2013

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000354984

Subject(s) - house dust mite , immunology , eosinophil , inflammation , eotaxin , mast cell , allergic inflammation , bronchoalveolar lavage , immunoglobulin e , ovalbumin , biology , lung , allergy , immune system , allergen , medicine , asthma , antibody

Mast cells are implicated in allergic and innate immune responses in asthma, although their role in models using an allergen relevant for human disease is incompletely understood. House dust mite (HDM) allergy is common in asthma patients. Our aim was to investigate the role of mast cells in HDM-induced allergic lung inflammation.

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