Toll-Like Receptor 9 Is Required for Chronic Stress-Induced Immune Suppression | Zendy

Hui Li | Zendy; Jing Zhao | Zendy; Michael Chen | Zendy; Yang Fei Tan | Zendy; Xiaohua Yang | Zendy; Yi Caudle | Zendy; Deling Yin | Zendy

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Toll-Like Receptor 9 Is Required for Chronic Stress-Induced Immune Suppression

Author(s) -

Hui Li,

Jing Zhao,

Michael Chen,

Yang Fei Tan,

Xiaohua Yang,

Yi Caudle,

Deling Yin

Publication year - 2013

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000354610

Subject(s) - immune system , tlr9 , corticosterone , cytokine , terminal deoxynucleotidyl transferase , endocrinology , chronic stress , tunel assay , receptor , medicine , biology , immunology , downregulation and upregulation , apoptosis , gene expression , hormone , biochemistry , dna methylation , gene

Mental and physical stress can suppress the immune system in both humans and animals. The mechanism by which stress affects immune responses, however, remains poorly defined. Toll-like receptors (TLRs) play a key role in modulating immune responses and cell survival. The mechanisms by which TLRs modulate chronic stress are largely unexplored.

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