Clofibrate Induces Heme Oxygenase 1 Expression through a PPARa-Independent Mechanism in Human Cancer Cells | Zendy

Shuai Wang | Zendy; Bethany N. Hannafon | Zendy; Jundong Zhou | Zendy; Wei-Qun Ding | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Clofibrate Induces Heme Oxygenase 1 Expression through a PPARa-Independent Mechanism in Human Cancer Cells

Author(s) -

Shuai Wang,

Bethany N. Hannafon,

Jundong Zhou,

Wei-Qun Ding

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354524

Subject(s) - clofibrate , gene knockdown , heme oxygenase , peroxisome proliferator activated receptor , transcription factor , chemistry , cancer research , gene expression , signal transduction , biology , microbiology and biotechnology , heme , gene , endocrinology , biochemistry , enzyme

Clofibrate, an established PPARα ligand, has recently been shown to have anticancer activity yet its mechanisms of action remain to be characterized. This study examined the effect of clofibrate on heme oxygenase-1 (HO-1) gene expression in A2780 (human ovarian cancer) and DU145 (human prostate cancer) cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research