Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway | Zendy

Yan Meng | Zendy; Chen Chen | Zendy; Lei Wang | Zendy; Xia Wang | Zendy; Cui Tian | Zendy; Jie Du | Zendy; Huihua Li | Zendy

Open Access

Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

Author(s) -

Yan Meng,

Chen Chen,

Lei Wang,

Xia Wang,

Cui Tian,

Jie Du,

Huihua Li

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354509

Subject(s) - tlr2 , tlr4 , agonist , ubiquitin ligase , signal transduction , peptidoglycan , ubiquitin , microbiology and biotechnology , toll like receptor , receptor , tlr9 , chemistry , innate immune system , biology , gene expression , biochemistry , dna methylation , enzyme , gene

Peptidoglycan (PGN) is a component of cell wall in Gram-positive bacteria that stimulates inflammatory responses through Toll-like receptor 2 (TLR2). The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)-interacting protein (CHIP, also known as Stub1) is a U-box-type E3 ubiquitin ligase, which plays an important role in protein quality control and inflammation through ubquitin-mediated proteasomal degradation. However, it is unclear whether TLR2 agonist PGN regulates the expression and activation of CHIP.

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