Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway | Zendy

Fan Yang | Zendy; Hongyang Chen | Zendy; Yanju Liu | Zendy; Kun Yin | Zendy; Yang Wang | Zendy; Xingda Li | Zendy; Guohui Wang | Zendy; Siyue Wang | Zendy; Xueying Tan | Zendy; Chaoqian Xu | Zendy; Yanjie Lu | Zendy; Benzhi Cai | Zendy

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Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Author(s) -

Fan Yang,

Hongyang Chen,

Yanju Liu,

Kun Yin,

Yang Wang,

Xingda Li,

Guohui Wang,

Siyue Wang,

Xueying Tan,

Chaoqian Xu,

Yanjie Lu,

Benzhi Cai

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354507

Subject(s) - doxorubicin , apoptosis , p38 mitogen activated protein kinases , mapk/erk pathway , microbiology and biotechnology , cancer research , chemistry , mesenchymal stem cell , biology , phosphorylation , medicine , biochemistry , chemotherapy

Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim of this study is to investigate if doxorubicin causes the apoptosis of BMSCs and in turn impairs its healing ability.

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