Gestational Undernourishment Modifies the Composition of Skeletal Muscle Transverse Tubule Membranes and the Mechanical Properties of Muscles in Newborn Rats | Zendy

Ricardo Tonathiu Ramírez-Oseguera | Zendy; Aura M. Jiménez-Garduño | Zendy; Rocío Álvarez Medina | Zendy; K Heine | Zendy; Enrique Pinzón-Estrada | Zendy; Ismael Torres-Saldaña | Zendy; Alicia Ortega Aguilar | Zendy

Open Access

Gestational Undernourishment Modifies the Composition of Skeletal Muscle Transverse Tubule Membranes and the Mechanical Properties of Muscles in Newborn Rats

Author(s) -

Ricardo Tonathiu Ramírez-Oseguera,

Aura M. Jiménez-Garduño,

Rocío Álvarez Medina,

K Heine,

Enrique Pinzón-Estrada,

Ismael Torres-Saldaña,

Alicia Ortega Aguilar

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354503

Subject(s) - skeletal muscle , endocrinology , medicine , glucose transporter , offspring , chemistry , fetus , biology , insulin , pregnancy , genetics

[corrected] Skeletal muscle (SM) constitutes more than 40% of the body weight in adulthood. Transports dietary glucose mainly through the insulin-dependent glucose transporter (Glut-4) located in the Transverse tubule membrane system (TT). The TT development ends shortly after birth. The TT membrane hosts the proteins involved in excitation-contraction coupling and glucose uptake. Glycaemic regulation through movement is a key function of fully developed skeletal muscle. In this study, we aimed to characterize the effect of gestational undernourishment (GUN) in rats GLUT-4 expression and on the protein/lipid content of the TT membranes. We also examined the effect of GUN on the mechanical properties of muscles as an indication of the metabolic condition of the SM at birth.

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