Advanced Oxidation Protein Products Induce Inflammatory Response in Fibroblast-Like Synoviocytes through NADPH Oxidase -Dependent Activation of NF-κB | Zendy

Shuai Zheng | Zendy; Zhaoming Zhong | Zendy; Shuai Qin | Zendy; Guo-Xian Chen | Zendy; Qian Wu | Zendy; JiHuan Zeng | Zendy; Wenbin Ye | Zendy; Wěi Li | Zendy; Kai Yuan | Zendy; Ling Yao | Zendy; Jian-Ting Chen | Zendy

Open Access

Advanced Oxidation Protein Products Induce Inflammatory Response in Fibroblast-Like Synoviocytes through NADPH Oxidase -Dependent Activation of NF-κB

Author(s) -

Shuai Zheng,

Zhaoming Zhong,

Shuai Qin,

Guo-Xian Chen,

Qian Wu,

JiHuan Zeng,

Wenbin Ye,

Wěi Li,

Kai Yuan,

Ling Yao,

Jian-Ting Chen

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354500

Subject(s) - nadph oxidase , chemistry , nf κb , fibroblast , microbiology and biotechnology , inflammation , nfkb1 , oxidative stress , reactive oxygen species , inflammatory response , signal transduction , biochemistry , biology , immunology , transcription factor , in vitro , gene

Advanced oxidation protein products (AOPPs), a marker of oxidative stress, are prevalent in many kinds of disorders. Rheumatoid arthritis (RA), mainly resulting from the dysfunction of fibroblast-like synoviocytes (FLSs), is related to oxidative stress. Although the increased levels of AOPPs in RA patients were reported, the effect of AOPPs on FLSs function still remains unclear. Therefore, our study aims to investigate whether AOPPs have an effect on the inflammatory response of FLSs in vitro.

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