Open AccessSTAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose
Author(s) -
Bin Dai,
Meng Cui,
Mei Zhu,
Wenling Su,
Ming-cai Qiu,
Hong Zhang
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354499
Subject(s) - cardiac fibrosis , phosphorylation , stat3 , cell growth , chemistry , signal transduction , mapk/erk pathway , western blot , medicine , biology , microbiology and biotechnology , endocrinology , cancer research , fibrosis , biochemistry , gene
Hyperglycaemia promotes the proliferation of cardiac fibroblasts (CFs) and collagen synthesis in CFs. However, the molecular mechanism underlying the effects of HG on proliferation and collagen synthesis of CF, is not completely understood.
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