Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity | Zendy

Wen-Wei Liang | Zendy; Kewei Ren | Zendy; Feng Liu | Zendy; Weiding Cui | Zendy; Qing Wang | Zendy; Zhefeng Chen | Zendy; Weimin Fan | Zendy

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Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity

Author(s) -

Wen-Wei Liang,

Kewei Ren,

Feng Liu,

Weiding Cui,

Qing Wang,

Zhefeng Chen,

Weimin Fan

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354495

Subject(s) - focal adhesion , phosphorylation , tyrosine phosphorylation , proto oncogene tyrosine protein kinase src , chemistry , integrin , microbiology and biotechnology , rac1 , chondrocyte , signal transduction , stress fiber , biology , biochemistry , cell , in vitro

The biological effects of periodic mechanical stress on chondrocytes have been studied extensively over the past few years. However, the mechanisms underlying chondrocyte mechanosensing and signaling in response to periodic mechanical stress remain to be determined. In the current study, we examined the effects of focal adhesion kinase (FAK) signaling on periodic mechanical stress-induced chondrocyte proliferation and matrix synthesis.

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