Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683 | Zendy

Syeda Tasneem Towhid | Zendy; Guilai Liu | Zendy; Teresa F. Ackermann | Zendy; Norbert Beier | Zendy; Wolfgang Scholz | Zendy; Thomas Fuchß | Zendy; Mahmoud Toulany | Zendy; H. Peter Rodemann | Zendy; Florian Läng | Zendy

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Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683

Author(s) -

Syeda Tasneem Towhid,

Guilai Liu,

Teresa F. Ackermann,

Norbert Beier,

Wolfgang Scholz,

Thomas Fuchß,

Mahmoud Toulany,

H. Peter Rodemann,

Florian Läng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354486

Subject(s) - cancer research , proton pump inhibitor , medicine , chemistry , pharmacology

The serum and glucocorticoid inducible kinase SGK1, which was originally cloned from mammary tumor cells, is highly expressed in some but not all tumors. SGK1 confers survival to several tumor cells. Along those lines, the number of colonic tumors following chemical carcinogenesis was decreased in SGK1 knockout mice. Recently, a highly selective SGK inhibitor (EMD638683) has been developed. The present study explored whether EMD638683 affects survival of colon carcinoma cells in vitro and impacts on development of colonic tumors in vivo.

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