Age Sensitivity of NFκB Abundance and Programmed Cell Death in Erythrocytes Induced by NFκB Inhibitors | Zendy

Mehrdad Ghashghaeinia | Zendy; Judith C. A. Cluitmans | Zendy; Mahmoud Toulany | Zendy; Mohammad Saki | Zendy; Martin Köberle | Zendy; Elisabeth Lang | Zendy; Peter Dreischer | Zendy; Tilo Biedermann | Zendy; Michael Duszenko | Zendy; Florian Läng | Zendy; G.J.C.G.M. Bosman | Zendy; Thomas Wieder | Zendy

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Age Sensitivity of NFκB Abundance and Programmed Cell Death in Erythrocytes Induced by NFκB Inhibitors

Author(s) -

Mehrdad Ghashghaeinia,

Judith C. A. Cluitmans,

Mahmoud Toulany,

Mohammad Saki,

Martin Köberle,

Elisabeth Lang,

Peter Dreischer,

Tilo Biedermann,

Michael Duszenko,

Florian Läng,

G.J.C.G.M. Bosman,

Thomas Wieder

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354481

Subject(s) - parthenolide , phosphatidylserine , annexin , apoptosis , band 3 , nf κb , chemistry , microbiology and biotechnology , programmed cell death , biology , pharmacology , biochemistry , membrane protein , membrane , phospholipid

Erythrocytes may enter eryptosis, a suicidal death characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte outer membrane. Susceptibility to eryptosis is enhanced in aged erythrocytes and stimulated by NFκB-inhibitors Bay 11-7082 and parthenolide. Here we explored whether expression of NFκB and susceptibility to inhibitor-induced eryptosis is sensitive to erythrocyte age.

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