Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice | Zendy

Christina Leibrock | Zendy; Teresa F. Ackermann | Zendy; Michael Hierlmeier | Zendy; Florian Läng | Zendy; Stefan Borgwardt | Zendy; Undine E. Lang | Zendy

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Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice

Author(s) -

Christina Leibrock,

Teresa F. Ackermann,

Michael Hierlmeier,

Florian Läng,

Stefan Borgwardt,

Undine E. Lang

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354478

Subject(s) - behavioural despair test , elevated plus maze , protein kinase b , open field , morris water navigation task , anxiety , neurotrophic factors , psychology , mood disorders , gsk 3 , pi3k/akt/mtor pathway , brain derived neurotrophic factor , knockout mouse , akt2 , neuroscience , antidepressant , medicine , endocrinology , psychiatry , signal transduction , akt1 , hippocampus , biology , biochemistry , receptor

The economic burden associated with major depressive disorder and anxiety disorders render both disorders the most common and debilitating psychiatric illnesses. To date, the exact cellular and molecular mechanisms underlying the pathophysiology, successful treatment and prevention of these highly associated disorders have not been identified. Akt2 is a key protein in the phosphatidylinositide-3 (PI3K) / glycogen synthase 3 kinase (GSK3) signaling pathway, which in turn is involved in brain-derived neurotrophic factor (BDNF) effects on fear memory, mood stabilisation and action of several antidepressant drugs. The present study thus explored the impact of Akt2 on behaviour of mice.

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