Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells | Zendy

Ioana Alesutan | Zendy; Jan Seifert | Zendy; Tatsiana Pakladok | Zendy; Johannes Rheinlaender | Zendy; Aleksandra Lebedeva | Zendy; Syeda Tasneem Towhid | Zendy; Christos Stournaras | Zendy; Jakob Voelkl | Zendy; Tilman E. Schäffer | Zendy; Florian Läng | Zendy

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Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

Author(s) -

Ioana Alesutan,

Jan Seifert,

Tatsiana Pakladok,

Johannes Rheinlaender,

Aleksandra Lebedeva,

Syeda Tasneem Towhid,

Christos Stournaras,

Jakob Voelkl,

Tilman E. Schäffer,

Florian Läng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354475

Subject(s) - microbiology and biotechnology , cytoskeleton , focal adhesion , actin , actin cytoskeleton , gene silencing , endothelial stem cell , microfilament , chemistry , biology , cell , phosphorylation , biochemistry , in vitro , gene

Endothelial cell stiffness plays a key role in endothelium-dependent control of vascular tone and arterial blood pressure. Actin polymerization and distribution of microfilaments is essential for mechanical cell stiffness. Chorein, a protein encoded by the VPS13A gene, defective in chorea-acanthocytosis (ChAc), is involved in neuronal cell survival as well as cortical actin polymerization of erythrocytes and blood platelets. Chorein is expressed in a wide variety of further cells, yet nothing is known about the impact of chorein on cells other than neurons, erythrocytes and platelets. The present study explored whether chorein is expressed in human umbilical vein endothelial cells (HUVECs) and addressed the putative role of chorein in the regulation of cytoskeletal architecture, stiffness and survival of those cells.

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