SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2 Cardiomyoblast Cells | Zendy

Ban Liu | Zendy; Wenliang Che | Zendy; Jinsong Xue | Zendy; Changzhu Zheng | Zendy; Kai Tang | Zendy; Jingying Zhang | Zendy; Jing Wen | Zendy; Yawei Xu | Zendy

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SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2 Cardiomyoblast Cells

Author(s) -

Ban Liu,

Wenliang Che,

Jinsong Xue,

Changzhu Zheng,

Kai Tang,

Jingying Zhang,

Jing Wen,

Yawei Xu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354469

Subject(s) - apoptosis , hypoxia (environmental) , microbiology and biotechnology , caspase 3 , caspase , sirtuin , cell , programmed cell death , caspase 2 , biology , chemistry , biochemistry , acetylation , gene , organic chemistry , oxygen

Apoptosis plays a critical role in cardiomyocyte loss during ischaemic heart injury. A detailed understanding of the mechanism involved has a substantial impact on the optimization and development of treatment strategies. Here, we report that the expression of SIRT4, a mitochondrial sirtuin, is markedly down-regulated in hypoxia-induced apoptosis of H9c2 cardiomyoblast cells.

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