Open AccessAngiotensin II Induces C-Reactive Protein Expression via AT1-ROS-MAPK-NF-κB Signal Pathway in Hepatocytes
Author(s) -
Jingjing Zhao,
Juntian Liu,
Xiaoming Pang,
Shuyue Wang,
Di Wu,
Xiaolu Zhang,
Liuxin Feng
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354461
Subject(s) - losartan , angiotensin ii , pyrrolidine dithiocarbamate , reactive oxygen species , chemistry , angiotensin ii receptor type 1 , medicine , endocrinology , mapk/erk pathway , hepatocyte , western blot , signal transduction , nf κb , receptor , biology , in vitro , biochemistry , gene
C-reactive protein (CRP) participates in development of inflammatory diseases. Hepatocytes are a major contributor of circulating CRP. Although angiotensin II (Ang II) is known to evoke inflammatory response, it remains unknown whether Ang II induces CRP expression in hepatocytes. The present study observed effect of Ang II on CRP expression and the related signal pathway in hepatocytes.
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