Open AccessSUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells
Author(s) -
Mingyue Tan,
Xingyu Mu,
Bin Liu,
Yong Wang,
Erdun Bao,
Jianxin Qiu,
Yu Fan
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000354458
Subject(s) - microbiology and biotechnology , cancer cell , bladder cancer , chemistry , cancer research , cell migration , protease , cell , cancer , biology , medicine , enzyme , biochemistry
SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member which has an indispensable role in the regulation of NF-κB transcriptional activation and Wnt signaling. However, whether SENP2 plays a role in tumor metastasis is completely unknown.
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