Inhibition of Histone Deacetylases Potentiates BMP9-Induced Osteogenic Signaling in Mouse Mesenchymal Stem Cells | Zendy

Ning Hu | Zendy; Changdong Wang | Zendy; Xi Liang | Zendy; Liangjun Yin | Zendy; Xiaoji Luo | Zendy; Bo Liu | Zendy; Hongyu Zhang | Zendy; Wei Shui | Zendy; Guoxin Nan | Zendy; Ning Wang | Zendy; Ningning Wu | Zendy; Xian Chen | Zendy; Yunfeng He | Zendy; Sheng Wen | Zendy; Fang Deng | Zendy; Hongmei Zhang | Zendy; Zhan Liao | Zendy; Hue H. Luu | Zendy; Rex C. Haydon | Zendy; TongChuan He | Zendy; Wei Huang | Zendy

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Inhibition of Histone Deacetylases Potentiates BMP9-Induced Osteogenic Signaling in Mouse Mesenchymal Stem Cells

Author(s) -

Ning Hu,

Changdong Wang,

Xi Liang,

Liangjun Yin,

Xiaoji Luo,

Bo Liu,

Hongyu Zhang,

Wei Shui,

Guoxin Nan,

Ning Wang,

Ningning Wu,

Xian Chen,

Yunfeng He,

Sheng Wen,

Fang Deng,

Hongmei Zhang,

Zhan Liao,

Hue H. Luu,

Rex C. Haydon,

TongChuan He,

Wei Huang

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354453

Subject(s) - mesenchymal stem cell , microbiology and biotechnology , stem cell , cancer research , signal transduction , chemistry , histone , biology , biochemistry , gene

We have demonstrated that bone morphogenetic protein 9 (BMP9) is one of the most potent BMPs in regulating osteoblast differentiation of mesenchymal stem cells (MSCs) although the molecular mechanism underlying BMP9-induced osteogenesis remains to be fully elucidated. It is known that epigenetic regulations play an important role in regulating the stem cell potency and lineage commitment. Here, we investigate if the inhibition of histone deacetylases (Hdacs) affects BMP9-induced osteogenic differentiation of MSCs.

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