AICAR Sustains J1 Mouse Embryonic Stem Cell Self-Renewal and Pluripotency by Regulating Transcription Factor and Epigenetic Modulator Expression | Zendy

Xiaoyan Shi | Zendy; Yongyan Wu | Zendy; Zhiying Ai | Zendy; Xin Liu | Zendy; Liping Yang | Zendy; Juan Du | Zendy; Jingjing Shao | Zendy; Zekun Guo | Zendy; Yong Zhang | Zendy

Open Access

AICAR Sustains J1 Mouse Embryonic Stem Cell Self-Renewal and Pluripotency by Regulating Transcription Factor and Epigenetic Modulator Expression

Author(s) -

Xiaoyan Shi,

Yongyan Wu,

Zhiying Ai,

Xin Liu,

Liping Yang,

Juan Du,

Jingjing Shao,

Zekun Guo,

Yong Zhang

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354451

Subject(s) - embryonic stem cell , microbiology and biotechnology , transcription factor , epigenetics , rex1 , stem cell , biology , cell potency , induced pluripotent stem cell , genetics , gene

[corrected] Embryonic stem cells (ES cells) have the capacity to propagate indefinitely, maintain pluripotency, and differentiate into any cell type under defined conditions. As a result, they are considered to be the best model system for research into early embryonic development. AICA ribonucleotide (AICAR) is an activator of AMP-activated protein kinase (AMPK) that is thought to affect ES cell function, but its role in ES cell fate decision is unclear.

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