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[corrected] Embryonic stem cells (ES cells) have the capacity to propagate indefinitely, maintain pluripotency, and differentiate into any cell type under defined conditions. As a result, they are considered to be the best model system for research into early embryonic development. AICA ribonucleotide (AICAR) is an activator of AMP-activated protein kinase (AMPK) that is thought to affect ES cell function, but its role in ES cell fate decision is unclear.

AICAR Sustains J1 Mouse Embryonic Stem Cell Self-Renewal and Pluripotency by Regulating Transcription Factor and Epigenetic Modulator Expression