Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization FollowingClostridium DifficileToxin Exposure of the Caco-2 Epithelial Cell Line | Zendy

Joshua Y. Lee | Zendy; Simon A. Hirota | Zendy; Louise Glover | Zendy; Glen D. Armstrong | Zendy; Paul L. Beck | Zendy; Justin A. MacDonald | Zendy

Open Access

Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization FollowingClostridium DifficileToxin Exposure of the Caco-2 Epithelial Cell Line

Author(s) -

Joshua Y. Lee,

Simon A. Hirota,

Louise Glover,

Glen D. Armstrong,

Paul L. Beck,

Justin A. MacDonald

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354448

Subject(s) - clostridium difficile toxin a , nitric oxide , toxin , clostridium difficile toxin b , nitric oxide synthase , caco 2 , reactive oxygen species , chemistry , microbiology and biotechnology , biochemistry , in vitro , biology , clostridium difficile , organic chemistry , antibiotics

Stabilization of the hypoxia-inducible factor (HIF-1α) is proposed to provide a protective host-response to C. difficile intoxication. Here, we aimed to elucidate whether nitric oxide and/or reactive oxygen species produced during C. difficile toxin exposure could influence HIF-1α stability and initiate protection against epithelial cell damage.

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