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Stabilization of the hypoxia-inducible factor (HIF-1α) is proposed to provide a protective host-response to C. difficile intoxication. Here, we aimed to elucidate whether nitric oxide and/or reactive oxygen species produced during C. difficile toxin exposure could influence HIF-1α stability and initiate protection against epithelial cell damage.

cellular physiology and biochemistry

Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization Following<b><i>Clostridium Difficile</i></b>Toxin Exposure of the Caco-2 Epithelial Cell Line

Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization FollowingClostridium DifficileToxin Exposure of the Caco-2 Epithelial Cell Line