Progesterone Negatively Regulates BCRP in Progesterone Receptor-Positive Human Breast Cancer Cells | Zendy

Xiaojuan Wu | Zendy; Xiaofang Zhang | Zendy; Limin Sun | Zendy; Hui Zhang | Zendy; Li Li | Zendy; Xiao Wang | Zendy; Weiwei Li | Zendy; Peng Su | Zendy; Jing Hu | Zendy; Peng Gao | Zendy; Gengyin Zhou | Zendy

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Progesterone Negatively Regulates BCRP in Progesterone Receptor-Positive Human Breast Cancer Cells

Author(s) -

Xiaojuan Wu,

Xiaofang Zhang,

Limin Sun,

Hui Zhang,

Li Li,

Xiao Wang,

Weiwei Li,

Peng Su,

Jing Hu,

Peng Gao,

Gengyin Zhou

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354442

Subject(s) - progesterone receptor , receptor , oestrogen receptor , endocrinology , cancer research , medicine , breast cancer , cancer , biology , chemistry , estrogen receptor

Breast cancer resistance protein (BCRP) plays a crucial role in multidrug resistance (MDR). Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. The presence of a progesterone response element (PRE) in the BCRP promoter, suggests that PROG may regulate transcription of BCRP.

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