Patulin-Induced Suicidal Erythrocyte Death | Zendy

Adrian Lupescu | Zendy; Kashif Jilani | Zendy; Mohanad Zbidah | Zendy; Florian Läng | Zendy

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Patulin-Induced Suicidal Erythrocyte Death

Author(s) -

Adrian Lupescu,

Kashif Jilani,

Mohanad Zbidah,

Florian Läng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354437

Subject(s) - patulin , phosphatidylserine , annexin , apoptosis , programmed cell death , annexin a5 , microbiology and biotechnology , mycotoxin , chemistry , biology , biochemistry , membrane , food science , phospholipid

Patulin, the most common mycotoxin in apples and apple-derived products, triggers apoptosis and has thus been considered for the treatment of cancer. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and by cell membrane scrambling leading to phosphatidylserine-exposure at the erythrocyte surface. Stimulators of eryptosis include increase of cytosolic Ca(2+)-activity ([Ca(2+)]i). The present study explored, whether exposure of human erythrocytes to patulin is followed by eryptosis.

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