Effect of DHA and CoenzymeQ10 Against A�- and Zinc-Induced Mitochondrial Dysfunction in Human Neuronal Cells | Zendy

Nadia Sadli | Zendy; Colin J. Barrow | Zendy; Sean L. McGee | Zendy; Cenk Suphioglu | Zendy

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Effect of DHA and CoenzymeQ10 Against A�- and Zinc-Induced Mitochondrial Dysfunction in Human Neuronal Cells

Author(s) -

Nadia Sadli,

Colin J. Barrow,

Sean L. McGee,

Cenk Suphioglu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000354433

Subject(s) - coenzyme q10 , mitochondrion , neuroprotection , neurotoxicity , docosahexaenoic acid , microbiology and biotechnology , neurodegeneration , biology , pharmacology , oxidative stress , reactive oxygen species , autophagy , chemistry , biochemistry , apoptosis , toxicity , medicine , fatty acid , disease , polyunsaturated fatty acid

Beta-amyloid (Aβ) protein is a key factor in the pathogenesis of Alzheimer's disease (AD) and it has been reported that mitochondria is involved in the biochemical pathway by which Aβ can lead to neuronal dysfunction. Coenzyme Q10 (CoQ10) is an essential cofactor involved in the mitochondrial electron transport chain and has been suggested as a potential therapeutic agent in AD. Zinc toxicity also affects cellular energy production by decreasing oxygen consumption rate (OCR) and ATP turnover in human neuronal cells, which can be restored by the neuroprotective effect of docosahexaenoic acid (DHA).

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