Role of p66shc in Renal Toxicity of Oleic Acid | Zendy

István Arany | Zendy; Jeb S. Clark | Zendy; Dustin K Reed | Zendy; Luis A. Juncos | Zendy; Mehul Dixit | Zendy

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Role of p66shc in Renal Toxicity of Oleic Acid

Author(s) -

István Arany,

Jeb S. Clark,

Dustin K Reed,

Luis A. Juncos,

Mehul Dixit

Publication year - 2013

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000354357

Subject(s) - oxidative stress , reactive oxygen species , mitochondrial ros , endocrinology , medicine , oxidative phosphorylation , chemistry , biochemistry

Adult and childhood obesity is an independent risk factor in development of chronic kidney disease (CKD) and its progression to end-stage kidney disease. Pathologic consequences of obesity include non-esterified fatty acid-induced oxidative stress and consequent injury. Since the serine36-phosphorylated p66shc is a newly recognized mediator of oxidative stress and kidney injury, we studied its role in oleic acid (OA)-induced production of reactive oxygen species (ROS), mitochondrial depolarization and injury in cultured renal proximal tubule cells.

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