hCLCA1 DNA Vaccine Suppresses Cell Hyperplasia and Mucin Expression of Goblet Cells in vitro | Zendy

Liqiang Song | Zendy; Yan Li | Zendy; Weihua Li | Zendy; Wei Zhang | Zendy; Y.Q. Yang | Zendy; Houbao Qi | Zendy

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hCLCA1 DNA Vaccine Suppresses Cell Hyperplasia and Mucin Expression of Goblet Cells in vitro

Author(s) -

Liqiang Song,

Yan Li,

Weihua Li,

Wei Zhang,

Y.Q. Yang,

Houbao Qi

Publication year - 2013

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000354180

Subject(s) - mucin , mucus , goblet cell , microbiology and biotechnology , cytokine , immunology , flow cytometry , medicine , biology , pathology , epithelium , ecology

Excessive airway mucus secretion is a remarkable trait of asthma. Mucus overproduction mainly resulted from an increase in goblet cell numbers, which causes considerable damage to health. However, effective therapeutic treatments are still lacking for mucus hypersecretion. Human calcium-activated chloride channel 1 (hCLCA1) has been identified to be predominantly responsible for mucus hypersecretion.

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