Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease | Zendy

Hye-Soo Yoo | Zendy; Yoo Seob Shin | Zendy; Jing Nan Liu | Zendy; MiAe Kim | Zendy; HaeSim Park | Zendy

Open Access

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Author(s) -

Hye-Soo Yoo,

Yoo Seob Shin,

Jing Nan Liu,

MiAe Kim,

HaeSim Park

Publication year - 2013

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000353976

Subject(s) - immunoglobulin e , superantigen , immunology , allergy , medicine , eosinophil , asthma , antibody , immune system , t cell

Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD.

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