Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents | Zendy

Claudia Brufani | Zendy; Antonino Crinò | Zendy; Danilo Fintini | Zendy; Patrizia Ippolita Patera | Zendy; Marco Cappa | Zendy; Melania Manco | Zendy

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Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

Author(s) -

Claudia Brufani,

Antonino Crinò,

Danilo Fintini,

Patrizia Ippolita Patera,

Marco Cappa,

Melania Manco

Publication year - 2013

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000353760

Subject(s) - metformin , medicine , insulin resistance , discontinuation , childhood obesity , obesity , type 2 diabetes , weight loss , placebo , insulin , overweight , endocrinology , diabetes mellitus , alternative medicine , pathology

Childhood obesity has become epidemic and has been accompanied by an increase in prevalence of type 2 diabetes (T2DM) in youth. Addressing obesity and insulin resistance by drug treatment represents a rational strategy for the prevention of T2DM. A systematic review was performed to evaluate the effectiveness of metformin in reducing weight and ameliorating insulin resistance in obese nondiabetic children.

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