Open AccessPrefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease
Author(s) -
Elliott J. Mufson,
Sarah Ward,
Lester I. Binder
Publication year - 2013
Publication title -
neurodegenerative diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 57
eISSN - 1660-2862
pISSN - 1660-2854
DOI - 10.1159/000353687
Subject(s) - basal forebrain , cognition , cognitive decline , alzheimer's disease , senile plaques , dementia , disease , amyloid (mycology) , psychology , cholinergic neuron , cognitive impairment , neuroscience , cholinergic , medicine , pathology
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. Here, we review data suggesting that prefibrillar tau oligomers mediate cognitive decline early in the disease.
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