Interactions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils | Zendy

Sarah Casulli | Zendy; Carole Elbim | Zendy

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Interactions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils

Author(s) -

Sarah Casulli,

Carole Elbim

Publication year - 2013

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000353588

Subject(s) - innate immune system , immunology , human immunodeficiency virus (hiv) , immune system , immunodeficiency , first line , immunity , biology , virus , microbiology and biotechnology , virology , disease , medicine , pathology

Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.

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