Open AccessInteractions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils
Author(s) -
Sarah Casulli,
Carole Elbim
Publication year - 2013
Publication title -
journal of innate immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.078
H-Index - 64
eISSN - 1662-8128
pISSN - 1662-811X
DOI - 10.1159/000353588
Subject(s) - innate immune system , immunology , human immunodeficiency virus (hiv) , immune system , immunodeficiency , first line , immunity , biology , virus , microbiology and biotechnology , virology , disease , medicine , pathology
Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.