L-Carnitine Ameliorates L-Asparaginase-Induced Acute Liver Toxicity in Steatotic Rat Livers | Zendy

Anne Roesmann | Zendy; Mamdouh Afify | Zendy; Jens Panse | Zendy; Albrecht Eisert | Zendy; Julia Steitz | Zendy; René H. Tolba | Zendy

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L-Carnitine Ameliorates L-Asparaginase-Induced Acute Liver Toxicity in Steatotic Rat Livers

Author(s) -

Anne Roesmann,

Mamdouh Afify,

Jens Panse,

Albrecht Eisert,

Julia Steitz,

René H. Tolba

Publication year - 2013

Publication title -

chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 54

eISSN - 1421-9794

pISSN - 0009-3157

DOI - 10.1159/000353402

Subject(s) - toxicity , carnitine , lactate dehydrogenase , glutathione , pharmacology , asparaginase , cytotoxicity , fatty liver , chemotherapy , hepatocyte , steatosis , medicine , endocrinology , biology , biochemistry , in vitro , enzyme , lymphoblastic leukemia , disease , leukemia

Chemotherapy with L-asparaginase is associated with hepatotoxicity resulting in organ dysfunction in patients with preexisting liver disorders. This study investigated the protective effect of L-carnitine during chemotherapy in a steatotic rat liver model.

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