Requirement of Apoptosis-Inducing Kinase 1 for the Induction of Bronchial Asthma following Stimulation with Ovalbumin | Zendy

Eiko Takada | Zendy; Masae Furuhata | Zendy; Susumu Nakae | Zendy; Hidenori Ichijo | Zendy; Katsuko Sudo | Zendy; Junichiro Mizuguchi | Zendy

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Requirement of Apoptosis-Inducing Kinase 1 for the Induction of Bronchial Asthma following Stimulation with Ovalbumin

Author(s) -

Eiko Takada,

Masae Furuhata,

Susumu Nakae,

Hidenori Ichijo,

Katsuko Sudo,

Junichiro Mizuguchi

Publication year - 2013

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000353240

Subject(s) - ovalbumin , immunology , ask1 , cytokine , inflammation , proinflammatory cytokine , medicine , p38 mitogen activated protein kinases , kinase , immunoglobulin e , protein kinase a , biology , antibody , immune system , mitogen activated protein kinase kinase , microbiology and biotechnology

Bronchial asthma is a chronic inflammatory disease of the airway. Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase kinase kinase family, is activated by environmental stress and plays a crucial role in the induction of apoptosis and inflammation. To examine whether ASK1 is involved in the induction of bronchial asthma, we investigated the role of ASK1 using a genetic approach in the production of cytokines, as well as the development of airway hyperreactivity (AHR) and antibody responses using a murine airway inflammation model.

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