Drug-Induced Hypothermia as Beneficial Treatment before and after Cerebral Ischemia | Zendy

Flemming Fryd Johansen | Zendy; Henrik Hasseldam | Zendy; Rune Skovgaard Rasmussen | Zendy; Anne Sofie Bisgaard | Zendy; Peter K. Bonfils | Zendy; Steen Seier Poulsen | Zendy; Jacob Hansen-Schwartz | Zendy

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Drug-Induced Hypothermia as Beneficial Treatment before and after Cerebral Ischemia

Author(s) -

Flemming Fryd Johansen,

Henrik Hasseldam,

Rune Skovgaard Rasmussen,

Anne Sofie Bisgaard,

Peter K. Bonfils,

Steen Seier Poulsen,

Jacob Hansen-Schwartz

Publication year - 2013

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000352026

Subject(s) - hypothermia , ischemia , medicine , anesthesia , brain ischemia , cardiology

Hypothermia is still unproven as beneficial treatment in human stroke, although in animal models, conditioning the brain with hypothermia has induced tolerance to insults. Here, we delineate the feasibility of drug-induced mild hypothermia in reducing ischemic brain damage when conditioning before (preconditioning) and after (postconditioning) experimental stroke.

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