Next-Generation Sequence Analysis of Genes Associated with Obesity and Nonalcoholic Fatty Liver Disease-Related Cirrhosis in Extreme Obesity | Zendy

Glenn S. Gerhard | Zendy; Xin Chu | Zendy; G. Craig Wood | Zendy; Genevieve M. Gerhard | Zendy; Peter N. Benotti | Zendy; Anthony Petrick | Zendy; Jon Gabrielsen | Zendy; William E. Strodel | Zendy; Christopher D. Still | Zendy; George Argyropoulos | Zendy

Open Access

Next-Generation Sequence Analysis of Genes Associated with Obesity and Nonalcoholic Fatty Liver Disease-Related Cirrhosis in Extreme Obesity

Author(s) -

Glenn S. Gerhard,

Xin Chu,

G. Craig Wood,

Genevieve M. Gerhard,

Peter N. Benotti,

Anthony Petrick,

Jon Gabrielsen,

William E. Strodel,

Christopher D. Still,

George Argyropoulos

Publication year - 2013

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000351719

Subject(s) - missense mutation , genome wide association study , nonalcoholic fatty liver disease , candidate gene , exome sequencing , genetics , exome , obesity , fatty liver , biology , cirrhosis , genetic association , single nucleotide polymorphism , medicine , gene , genotype , disease , mutation

Genome-wide association studies (GWAS) have led to the identification of single nucleotide polymorphisms in or near several loci that are associated with the risk of obesity and nonalcoholic fatty liver disease (NAFLD). We hypothesized that missense variants in GWAS and related candidate genes may underlie cases of extreme obesity and NAFLD-related cirrhosis, an extreme manifestation of NAFLD.

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